Desktop Printers

Zebra ZD421 Advanced Desktop Printer

The ZD421 – Easy to operate. Flexible features. Future-ready.

Ethernet203 dpi300 dpi
ZD421cZD421c-HCZD421dZD421d-HCZD421tZD421t-HC
Zebra ZD421 Advanced Desktop Printer
Technical Specifications

Zebra ZD421 Advanced Desktop Printer

Print Method
Thermal transfer or direct thermal
Resolution
203 dpi300 dpi (optional)
Maximum Print Speed
6 in (152 mm) per second (203 dpi); 4 in (102 mm) per second (300 dpi)
Maximum Print Width
4,09 in (104 mm) at 203 dpi; 4,27 in/108 mm at 300 dpi
Operating System
Link-OS
Memory
512 MB flash memory; 256 MB SDRAM
Communications
Ethernet 10/100, 802.11ac Wi-Fi and Bluetooth 4.1 (dual-band radio); RS-232 serial interface, DB-9
Electrical
100 to 240 V AC, 50 to 60 Hz; ENERGY STAR certified; optional 2750 mAh battery
Operating Temperature
40 °F to 105 °F/4.4 °C to 41 °C
Label Length
Minimum: 0,25 in/6,4 mm; Maximum: 39,0 in/991 mm
Barcodes
1D (Code 39, Code 128, UPC/EAN) and 2D (PDF417, DataMatrix, QR Code, Aztec)
Total Configurations
29
Key Features

Standard Features

Print methods: thermal transfer or direct thermal, with ZPL and EPL programming languages

Five status icons and a three-button interface

USB 2.0, USB Host and a mobile printer setup app for Android and iOS over a Bluetooth Low Energy (BLE 5) connection

Real-time clock (RTC) and OpenACCESS™ for easy media loading

Double-wall frame construction and ENERGY STAR™ certification

ZebraDesigner Essentials: a simple label-design tool available free of charge

Healthcare models in white, with an IEC 60601-1 certified power supply

Easy-to-clean, disinfectant-ready plastics with a sealed button interface and UV-resistant housing that supports UV-light cleaning protocols

All Configurations

29 configurations

29 items
Part Number Model Description
ZD4A042-301E00EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4A042-D01E00EZ ZD421d Direct Thermal Printer ZD421; 203 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4A042-301M00EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL
ZD4A042-D01M00EZ ZD421d Direct Thermal Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL
ZD4A043-301E00EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 300 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4A043-301M00EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL
ZD4A042-301X01EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A043-D01M00EZ ZD421d Direct Thermal Printer ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL
ZD4AH42-D01E00EZ ZD421d-HC Direct Thermal Printer ZD421; Healthcare, 203 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4A043-D01E00EZ ZD421d Direct Thermal Printer ZD421; 300 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4AH43-301E00EZ ZD421t-HC Thermal Transfer Printer (74/300M) ZD421, Healthcare; 300 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4A042-C01E00EZ ZD421c Thermal Transfer Cartridge Printer ZD421; 203 dpi, USB, USB Host, Ethernet, BTLE5, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A042-D01X01EZ ZD421d Direct Thermal Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A043-301X01EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4AH42-C01E00EZ ZD421c-HC Thermal Transfer Cartridge Printer ZD421, Healthcare; 203 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4A042-301X02EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, ROW, US Cord, Swiss Font, EZPL
ZD4A043-D01X01EZ ZD421d Direct Thermal Printer ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A042-305E00EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Ethernet, BTLE5, Argentina Cord, Swiss Font, EZPL
ZD4A042-305M00EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, Argentina Cord, Swiss Font, EZPL
ZD4AH43-D01E00EZ ZD421d-HC Direct Thermal Printer ZD421; Healthcare, 300 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4A043-C01X01EZ ZD421c Thermal Transfer Cartridge Printer ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A042-C01M00EZ ZD421c Thermal Transfer Cartridge Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL
ZD4A043-C01E00EZ ZD421c Thermal Transfer Cartridge Printer ZD421; 300 dpi, USB, USB Host, Ethernet, BTLE5, USA/Canada, US Cord, Swiss Font, EZPL
ZD4AH43-C01E00EZ ZD421c-HC Thermal Transfer Cartridge Printer ZD421, Healthcare; 300 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4A043-30PE00EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 300 dpi, USB, USB Host, Ethernet, BTLE5, APAC Cord bundle (EU, UK, AUS, JP), Swiss Font, EZPL
ZD4A043-C01M00EZ ZD421c Thermal Transfer Cartridge Printer ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL
ZD4A043-30EE00EZ ZD421t Thermal Transfer Printer (74/300M) ZD421; 300 dpi, USB, USB Host, Ethernet, BTLE5, EU and UK Cords, Swiss Font, EZPL
ZD4A042-C01X01EZ ZD421c Thermal Transfer Cartridge Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4AH42-D01X01EZ ZD421d-HC Direct Thermal Printer ZD421; Healthcare, 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
Full Specifications

Zebra ZD421 Specifications

Specification Detail
DimensionsDirect thermal: 8,69 in L x 6,98 in W x 5,93 in H (220,8 mm x 177,5 mm x 150,7 mm). Thermal transfer with roll: 10,5 in L x 8,0 in W x 7,44 in H (267 mm x 202 mm x 189 mm). Thermal transfer with cartridge: 10,0 in L x 8,0 in W x 7,0 in H (254 mm x 202 mm x 177 mm)
WeightDirect thermal: 2,98 lb/1,35 kg. Thermal transfer with roll: 4,52 lb/2,05 kg. Thermal transfer with roll: 5,0 lb/2,3 kg
Operating systemLink-OS
Resolution203 dpi/8 dots per mm; 300 dpi (12 dots per mm), optional
Memory512 MB flash memory; 256 MB SDRAM; 64 MB non-volatile memory available to the user; 8 MB SDRAM available to the user
Maximum print width4,09 in (104 mm) at 203 dpi; 4,27 in/108 mm at 300 dpi; cartridge: 4,09 in/104 mm at 203 dpi and 300 dpi
Maximum print speed6 in (152 mm) per second (203 dpi); 4 in (102 mm) per second (300 dpi)
Media sensorsFull-width movable reflective sensor; multi-position gap/transmissive sensor
FirmwareZPL II; EPL 2; XML; ZBI; PDF Direct
Label lengthMinimum: 0,25 in/6,4 mm; Maximum: 39,0 in/991 mm
Media widthDirect thermal: from 0,585 in/15 mm to 4,25 in/108 mm. Thermal transfer with roll: from 0,585 in/15 mm to 4,41 in/112 mm. Thermal transfer with roll: from 0,585 in/15 mm to 4,65 in/118 mm
Media roll sizeMaximum outer diameter: 5,00 in/127 mm. Inner core diameter: 0,5 in (12,7 mm) and 1,0 in (25,4 mm) standard; 1,5 in (38,1 mm); 2,0 in (50,8 mm) and 3,0 in (76,2 mm) with optional adapters
Media thickness0,003 in (0,08 mm) min.; 0,0075 in (0,19 mm) max.
Media typesRoll-fed or fanfold die-cut or continuous media with or without black mark, tag stock, continuous receipt paper and wristbands
Ribbon outer diameter2,6 in/66 mm (300 m); 1,34 in/34 mm (74 m)
Standard ribbon lengthRoll: 984 ft (300 m); 243 ft (74 m). Cartridge: 243 ft (74 m)
Ribbon ratio1:4 ribbon to media (300 m); 1:1 ribbon to media (74 m)
Ribbon widthRoll: 1,33 in/33,8 mm — 4,3 in/109,2 mm. Cartridge: 4,3 in/109,2 mm
Ribbon core inner diameter300-meter ribbon: 1 in/25,4 mm. 74-meter ribbon: 0,5 in/12,7 mm
Operating temperature40 °F to 105 °F/4.4 °C to 41 °C
Storage temperature-40 °F to 140 °F/-40 °C to 60 °C
Operating humidity10% to 90% non-condensing
Storage humidity5% to 95% non-condensing
ElectricalAuto-detecting (PFC compliant) 100 to 240 V AC, 50 to 60 Hz; ENERGY STAR certified; Level VI energy-efficiency certified; optional 2750 mAh battery; healthcare models include an IEC60601-1 certified power supply
Media handlingDispenser/peeler: label peel and present with label-present sensor (field-installable); cutter (field-installable)
CommunicationsField-installable: Ethernet 10/100, 802.11ac Wi-Fi and Bluetooth 4.1 (dual-band radio); auto-detecting RS-232 serial interface, DB-9. Factory-installed: Ethernet 10/100, 802.11ac Wi-Fi and Bluetooth 4.1 (dual-band radio)
BatteryPowers the printer to print at maximum speed for full shifts; compatible with all connectivity and media-handling options
Carrying caseCarrying case with shoulder strap and handles to transport the desktop printer and battery to the installation site
Standalone keyboard displayZebra Keyboard Display Unit (ZKDU) for standalone printing solutions
Enclosed power supplyIncluded accessory for the power supply that conceals the cables
Barcode ratios2:1 and 3:1
1D barcodesCode 11, Code 39, Code 93, Code 128, ISBT-128, UPC-A, UPC-E, EAN-8, EAN-13, UPC and EAN with 2- or 5-digit extensions, Plessey, Postnet, Standard 2 of 5, Industrial 2 of 5, Interleaved 2 of 5, Logmars, MSI, Codabar and Planet Code
2D barcodesCodablock, PDF417, Code 49, DataMatrix, MaxiCode, QR Code, MicroPDF, Aztec
Fonts and graphics16 resident expandable ZPL II bitmap fonts, two resident scalable ZPL fonts, five resident expandable EPL2 fonts, native OpenType font support and Unicode compatible. China units include the SimSun simplified Chinese font
Agency approvalsIEC 60950-1, IEC 62368-1, EN55022 Class B, EN55024, EN55035, EN61000-3-2, EN61000-3-3, FCC Class B, ICES-003, FCC 15.209; 15.247(d), IC RSS 247, EN 300 328, EN 301 893, EN 62311, cTUVus, CE Mark, VCCI, C-Tick, S-Mark, CCC, CU, BSMI, KCC, SABS, IN-Metro, BIS, NOM
In the boxPrinter, empty ribbon take-up cores (1 in. and 0,5 in.), third-party 300 m ribbon spindle adapters (2), AC power supply, power cord(s), USB cable, quick-start guide, regulatory guide
WarrantyZD400 Series printers are warranted against defects in workmanship and materials for a minimum period of 2 (two) years from the date of shipment. Warranty varies by region.
Overview

About the Zebra ZD421

Raise your expectations with Zebra's advanced healthcare desktop printers. The ZD421 is easy to operate, offers flexible features and is future-ready, helping to power your healthcare workflows and support virtually any use case.

Ready for the challenges ahead, the ZD421 combines flexibility and advanced features with the Print DNA™ software suite — a built-in advantage that gets your printer up and running quickly and securely. As an authorized Zebra partner, Barrdega supplies the ZD421 with expert deployment guidance — request a quote for project pricing.

Interested in the Zebra ZD421 Advanced Desktop Printer?

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